The 38-year-old reality star was spotted with the dressing on her left cheek while rollerskating with her sisters in Los Angeles on Wednesday.
For the casual outing, the mother-of-two wore a baggy black hoodie and sweatpants with slides.
Fans were drawn in by a large flesh-colored bandage covering the lower half of her left cheek.
They shared their fears on Reddit, with one writing: “Anyone else spots the huge bandage? I really hope she’s alright.”
Another suggested: “She could have burned herself? That’s a blister bandage.”
A third user speculated that it was a hydrocolloid bandage used to treat acne.
“I used those (hydrocolloid bandages aka giant pimple patches) when I had bad cystic acne that came in clusters.
“Worked better than anything and I tried it all.”
During a trip to Malibu beach with her daughter True, four, earlier this week, the Kardashians star appeared to have a bandage on her face.
Meanwhile, fans recently speculated that Khloe had her butt reduced to match her slimmer frame.
The reality star appeared to have a significantly reduced posterior while attending a recent screening of The Kardashians finale in a white catsuit.
Fans noticed Khloe’s buttocks had shrunk and speculated that her rumored implants had been removed.
Fans believe Khloe’s weight loss was caused by stress from her ex-boyfriend Tristan Thompson’s cheating scandal with his mistress, Maralee Nichols, who gave birth to his third child, Theo.
Khloe and Tristan’s second child was born in November 2021, just days before the former couple split over his love child scandal.
After a month of speculation, Tristan confirmed he is Theo’s father and apologized publicly to Khloe.
The athlete wrote on social media: “Today, paternity test results revealed that I fathered a child with Maralee Nichols.
“I take full responsibility for my actions. Now that paternity has been established, I looked forward to amicably raising our son.
“I sincerely apologize to everyone I’ve hurt or disappointed throughout this ordeal both publicly and privately.”
He then turned his attention directly to his ex, writing: “Khloe, you don’t deserve this. You don’t deserve the heartache and humiliation I have caused you.”